List of Models
|
MODEL |
CANCER TYPE |
CELL LINE |
|
Subcutaneous Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Colon |
CT26.WT (BALB/c), MC-38 (C57BL/6) |
|
|
Fibrosarcoma |
FSa-II (BALB/c) |
|
|
Lung |
LLC1 (C57BL/6) |
|
|
Melanoma |
B16/F10 (C57BL/6) |
|
|
Ovary |
ID8 (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Orthotopic Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Lung |
LLC1-Luc (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Metastasis Syngeneic Model |
Breast |
4T1-Luc-TdTomato (Mammary Fat Pad Injection) 4T1-Luc-TdTomato (Intracardiac Injection) 4T1-Luc-TdTomato (Intravenous Injection) |
|
Leukemia |
WEHI-3 (Mouse Leukemia) |
|
|
Spontaneous Model (GEM) |
Lung |
Induced by p53/ras mutation |
|
Genetically Engineered Mouse (GEM) |
Immuno-Oncology |
CTLA-4 knock-out mouse, PD-1 knock-out mouse |
Others |
Asan NSG mouse |
Service
- Customized study design ((in vitro, in vivo, ex vivo))
- Tumor growth inhibition/delay studies using mouse models
- Evaluation of monotherapy and combination therapy with immune-oncology drugs (e.g., anti-PD-(L)1, anti-CTLA4)
- Immune cell immunophenotyping Histological analysis within the tumor microenvironment using FACS (Tissue preparation, IHC, TUNEL)
- In vivo imaging
- Live animal IVIS imaging, MRI, PET, PET-MR, CT
- ADCC (Antibody-dependent cell mediated cytotoxicity), CDC (Complement dependent cytotoxicity) assay
- Treg (Regulatory T cell) suppression assay
- Metastasis inhibition assay
- Immuno-radiotherapy response assay
- Mouse tumor-infiltrated lymphocyte (TIL) analysis
- Human T cell analysis: MLR assay / CEFT assay / CMV Antigen Recall Assay
- PD-1:PD-L1 Inhibitor Screening Assay
Service example
Analysis of tumor-infiltrating lymphocytes within MC38 tumors