List of Models
|
MODEL |
CANCER TYPE |
Xenograft |
Syngeneic |
|
Subcutaneous |
Bladder |
UM-UC-3 |
|
|
Breast |
MCF7, MDA-MB-231 |
4T1, 4T1-Luc-TdTomato |
|
|
Burkitt’s lymphoma |
Raji |
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|
Cervix |
A431, CaSki |
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|
Colon |
DLD-1, HCT-8, HCT-15, HCT-116, HT-29, LoVo, RKO, SW620 |
CT26, MC38 |
|
|
Kidney |
SN12C |
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|
Leukemia |
K562, MV-4-11 |
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|
Liver |
Hep3B, HepG2, Huh7, SK-Hep1 |
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Lung |
A549, HCC78, HCC827, NCI-H69, NCI-H209, NCI-H460, NCI-H1299, PC9 |
LLC1 |
|
|
Melanoma |
UACC-62 |
B16-F10 |
|
|
Ovary |
OVCAR-3-Luc |
ID8 | |
|
Pancreas |
AsPC-1 (NOG mouse), BxPC-3, MiAPaCa-2 |
PAN 02 | |
|
Prostate |
DU145, PC3 |
TRAMP-C1 | |
|
Stomach |
NCI-N87 |
|
Orthotopic |
Breast |
4T1-Luc-TdTomato |
|
|
Colon |
HCT-116-Luc, HT-29-Luc |
|
|
|
Leukemia |
MOLM-13 |
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|
Lung |
A549-Luc |
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|
Ovary |
ES-2-Luc |
ID8-Luc |
|
|
Pancreas |
AsPC-1-Luc, BxPC-3-Luc |
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|
Prostate |
TRAMP-C1 |
|
Metastasis |
Breast |
4T1-Luc-TdTomato (Intracardiac Injection), 4T1-Luc-TdTomato (Intravenous Injection) |
|
|
Leukemia |
WEHI-3 |
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|
Ovary |
ES-2-Luc (Orthotopic Injection), OVCAR-3-Luc (Intraperitoneal Injection), SK-OV-3-Luc (Intraperitoneal Injection) |
|
Spontaneous Model |
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|
Lung |
Lung (Mutation: p53/ras) |
|
Genetically Engineered Mouse |
Immuno Oncology |
CTLA-4 Knock-out Mouse, PD-1 Knock-out Mouse |
|
Lung |
Ba/F3/Her2 insertion cell line, |
Service
- Customized study design
- Tumor growth inhibition/delay study
- Single treatment
- Combination treatment
- Kaplan-Meier survival analysis
- Metastasis inhibition study
- Radiotherapy response study
- Histological analysis
- Tissue preparation, IHC, TUNEL, DNA/RNA/protein extraction
- Histopathology
- MOA (Mechanism of Action) & POC (Proof of Concept) validation
- In vivo imaging study
- Utilizing MRI, PET, PET-MR, CT, and Optical imaging
- PD, tissue distribution
Service example
In vivo evaluation of antitumor efficacy in a
colorectal cancer subcutaneous xenograft model